SUMMARY — Seventy-one Burmese adult patients with lepromatous leprosy were treated with various regimens of rifampicin monotherapy, 450 mg. daily for 60 days or 900 mg. once weekly for 12 weeks or 450 mg. daily for six months. Of the patients, 18 had relapsed after stopping DDS therapy, 20 were intolerant of DDS, 18 were DDS resistant and 15 had received no previous treatment. Rifampicin produced a 75% reduction in the size of skin nodules in two thirds of the patients and a complete disappearance of nodules in the others. After one month drug treatment the MI fell to zero but the BI remained unchanged. The once weekly regimen was as effective as the daily treatment. Four patients had to be withdrawn due to ENL reactions. NOTE:The contents of this paper were presented at the Burma Medical Conference, 1977.